Journal
CANCERS
Volume 10, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/cancers10040108
Keywords
carcinoma; unknown primary site; diagnosis; immunohistochemistry
Categories
Funding
- Canceropole PACA
- Fondation ARC pour la Recherche sur le Cancer [ARC SL220110603478]
- CANC'AIR Genexposomic project
- Conseil Departemental des Alpes-Maritimes
- Region Provence Alpes-Cote d'Azur
Ask authors/readers for more resources
Immunohistochemistry has become an essential ancillary examination for the identification and classification of carcinomas of unknown primary site (CUPs). Over the last decade, the diagnostic accuracy of organ- or tumour-specific immunomarkers and the clinical validation of effective immunohistochemical panels has improved significantly. When dealing with small sample sizes, diagnostic accuracy is crucial, particularly in the current era of targeted molecular and immune-based therapies. Effective systematic use of appropriate immunohistochemical panels enables accurate classification of most of the undifferentiated carcinomas as well as careful preservation of tissues for potential molecular or other ancillary tests. This review discusses the algorithmic approach to the diagnosis of CUPs using CK7 and CK20 staining patterns. It outlines the most frequently used tissue-specific antibodies, provides some pitfalls essential in avoiding potential diagnostic errors and discusses the complementary tools, such as molecular tumour profiling and mutation-specific antibodies, for the improvement of diagnosis and prediction of the treatment response.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available