Journal
EBIOMEDICINE
Volume 30, Issue -, Pages 113-119Publisher
ELSEVIER
DOI: 10.1016/j.ebiom.2018.03.003
Keywords
Neuroblastoma; Susceptibility; ERCC1; XPF; Polymorphism
Funding
- Pearl River S&T Nova Programme of Guangzhou [201710010086]
- National Natural Science Foundation of China [81502046]
- State Clinical Key Specialty Construction Project (Paediatric Surgery) [GJLCZD1301]
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Variations in nucleotide excision repair pathway genes may predispose to initiation of cancers. However, polymorphisms of ERCC1/XPF genes and neuroblastoma risk have not been investigated before. To evaluate the relevance of polymorphisms of ERCC1/XPF genes in influencing neuroblastoma susceptibility, we genotyped four polymorphisms in ERCC1/XPF genes using a Chinese population of 393 cases and 812 controls. The results showed that ERCC1 rs2298881 and rs11615 predisposed to enhanced neuroblastoma risk [CA vs. AA: adjusted odds ratio (OR) = 1.94, 95% confidence interval (CI) = 1.30-2.89, P = 0.0012; CC vs. AA: adjusted OR = 2.18, 95% CI = 1.45-3.26, P = 0.0002 for rs2298881, and AG vs. GG: adjusted OR = 1.31, 95% CI = 1.02-1.69, P = 0.038 for rs11615]. Moreover, XPF rs2276466 was also associated with increased neuroblastoma risk (GG vs. CC: adjusted OR = 1.66, 95% CI = 1.02-2.71, P = 0.043). In the combined analysis of ERCC1, we found that carriers with 2-3 risk genotypes were more likely to get risk of neuroblastoma, when compared to those with 0-1 risk genotype (adjusted OR = 1.75; 95% CI = 1.25-2.45, P = 0.0012). Our study indicates that common genetic variations in ERCC1/XPF genes predispose to neuroblastoma risk, which needs to be further validated by ongoing efforts. (C) 2018 The Authors. Published by Elsevier B.V.
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