Journal
EBIOMEDICINE
Volume 30, Issue -, Pages 248-260Publisher
ELSEVIER
DOI: 10.1016/j.ebiom.2018.03.010
Keywords
White adipose tissue; Adipocytes; Long non-coding RNAs; Metabolic traits; Lipolysis; Adiponectin
Funding
- EU/EFPIA Innovative Medicines Initiative Joint Undertaking (EMIF grant) [115372]
- Novo Nordisk Foundation
- Tripartite Immuno-metabolism Consortium (TrIC) [NNF15CC0018486]
- MSAM consortium [NNF15SA0018346]
- Swedish Diabetes Association [DIA2013-003]
- CIMED
- Swedish Research Council [K2012-55X-01034-46-5]
- Stockholm County Council [20160040]
- EFSD
- Diabetes Program at Karolinska Institutet
- Novo Nordisk (Copenhagen, Denmark) Postdoctoral Fellowship Program at Karolinska Institutet
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Long non-coding RNAs (lncRNAs) belong to a recently discovered class of molecules proposed to regulate various cellular processes. Here, we systematically analyzed their expression in human subcutaneous white adipose tissue (WAT) and found that a limited set was differentially expressed in obesity and/or the insulin resistant state. Two lncRNAs herein termed adipocyte-specific metabolic related lncRNAs, ASMER-1 and ASMER-2 were enriched in adipocytes and regulated by both obesity and insulin resistance. Knockdown of either ASMER-1 or ASMER-2 by antisense oligonucleotides in in vitro differentiated human adipocytes revealed that both genes regulated adipogenesis, lipid mobilization and adiponectin secretion. The observed effects could be attributed to crosstalk between ASMERs and genes within the master regulatory pathways for adipocyte function including PPARG and INSR. Altogether, our data demonstrate that lncRNAs are modulators of the metabolic and secretory functions in human fat cells and provide an emerging link between WAT and common metabolic conditions. (C) 2018 The Authors. Published by Elsevier B.V.
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