Journal
GENOMICS PROTEOMICS & BIOINFORMATICS
Volume 16, Issue 1, Pages 10-16Publisher
ELSEVIER
DOI: 10.1016/j.gpb.2018.02.001
Keywords
Synthetic biology; Genome writing; Genome editing; Bioethics; Biosafety
Categories
Funding
- Guangdong Provincial Key Laboratory of Genome Read and Write [2017B030301011]
- Shenzhen Engineering Laboratory for Innovative Molecular Diagnostics [DRC-SZ[2016]884]
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The ultimate goal of synthetic biology is to build customized cells or organisms to meet specific industrial or medical needs. The most important part of the customized cell is a synthetic genome. Advanced genomic writing technologies are required to build such an artificial genome. Recently, the partially-completed synthetic yeast genome project represents a milestone in this field. In this mini review, we briefly introduce the techniques for de novo genome synthesis and genome editing. Furthermore, we summarize recent research progresses and highlight several applications in the synthetic genome field. Finally, we discuss current challenges and future prospects.
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