Journal
CHEM
Volume 4, Issue 5, Pages 1128-1138Publisher
CELL PRESS
DOI: 10.1016/j.chempr.2018.02.016
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Funding
- A*STAR (Agency for Science, Technology, and Research of Singapore) Biomedical Research Council
- National Medical Research Council [NMRC/TCR/016-NNI/2016]
- Ministry of Science & ICT (MSIT), Republic of Korea [IBS-R007-D1-2018-A00] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Elastic fibers are present in a variety of tissues and are responsible for their resilience. Until now, no optical contrast agent in the near-infrared (NIR) wavelength range of 700-900 nm has been reported for the imaging of elastic fibers. Here, we report the discovery of a NIR zwitterionic elastin probe ElaNIR (elastin NIR) through fluorescent-image-based screening. The probe was successfully applied for in vitro, ex vivo, and in vivo imaging by various imaging modalities. Age-related elastin differences shown by in vivo fluorescent and photoacoustic imaging indicated that ElaNIR can be a potentially convenient tool for uncovering changes of elastin in live models.
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