Metal-Free Selective C2-H Amidation of 8-Amidoquinolines by Using Isocyanide as the Source of Amide

An unanticipated and highly efficient selective amidation in the C2 position of 8-amidoquinolines has been developed via C-H bond elaboration. The method is transition-metal-free, operationally simple with broad functional group tolerance. In this work, isocyanide has been successfully utilized as the source of amide. Furthermore, various kinds of 8-amidoquinolines in combination with different substituted isocyanides under oxidative condition resulted in direct access to N-quinoline-2-carboxamides in good yields.