Journal
CHEMISTRYSELECT
Volume 3, Issue 25, Pages 7045-7048Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.201801344
Keywords
azides; cycloaddition; fluorine; triazoles; trifluoromethyl
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Funding
- Czech Academy of Sciences [RVO: 61388963]
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An effective synthesis of highly functionalized N-perfluoroalkyl-1,2,3-triazoles from azidoperfluoroalkanes has been achieved. In situ generated enamines readily participate in the azide-carbonyl [3 + 2] cycloaddition, providing a facile way to fully substituted triazole frameworks in good to excellent yields. The synthetic value of these triazoles was shown in the synthesis of perfluorinated 1,5-disubstituted triazoles by hydrolysis and decarboxylation.
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