Journal
CHEMISTRYSELECT
Volume 3, Issue 16, Pages 4406-4412Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.201800575
Keywords
Amide; Cobalt/copper catalyst; Cross coupling; Enamide; Styrenyl halide
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Funding
- Indian National Science Academy, New Delhi [SP/SS/2012/1654]
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An efficient C(sp2) - N cross coupling of cyclic and acyclic amides with styrenyl/aryl/heteroaryl halides catalyzed by cobalt acetylacetonate in combination with copper(I) iodide, has been achieved. A library of diversely substituted cyclic and acyclic enamides have been obtained in high yields by this procedure. The reaction is stereoselective producing (E)-enamides from trans-styrenyl halides and (Z)- products from cis-halides. This procedure has been successfully employed for the coupling of other N-heterocycles such as pyrazole, imidazole and triazole with aryl/styrenyl/heteroaryl halides to produce the corresponding N-coupled products. A probable mechanism has been suggested.
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