Cobalt-Copper Ferrite Nanoparticles Catalyzed Click Reaction at Room-Temperature: Green Access to 1,2,3-Triazole Derivatives

A typical Cobalt-Copper ferrite nanoparticles (CoCuFe2O4) was used as a catalyst for one-pot [3+2] cycloaddition of alkyl azides with alkynes at room temperature in green media. These nanoparticles were synthesized by using co-precipitation method and were fully characterized by physiochemical technique. By this catalyst system, various types of alkyl halides were coupled with alkynes efficiently to furnish 1,2,3 triazoles in excellent yields within short reaction time. The requirement on energy and time for the Click reaction extremely minimized in this method compared to previously reported reactions as an inevitable trend in development of green chemistry. Using green solvent, inexpensive catalyst, and ability to totally removal of catalyst from reaction media have made this protocol valuable from the green chemistry point of view.