Journal
CHEMISTRYSELECT
Volume 3, Issue 11, Pages 3208-3213Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.201800678
Keywords
biomimetic models; manganese; nonheme; reactivity; sulfoxidation
Categories
Funding
- National Natural Science Foundation of China [21003116, 21173211]
- State Key Laboratory of Molecular Reaction Dynamics
- National Supercomputer Center in Guangzhou
- Conacyt Mexico
Ask authors/readers for more resources
Metalloenzymes often utilize a high-valent metal-oxo species in their catalytic cycle that is formed through a combination of reduction/proton transfer steps from O-2. In biomimetic chemistry, by contrast, the use of molecular oxygen is challenging and instead addition of iodosylarenes as terminal oxidants generates these high-valent metal-oxo intermediates. There has been controversy in the literature for many years, whether the iodosylarene (or one of its side-products in a reaction with a metal center) can act as an active oxidant. Herein, we present a comprehensive theoretical study on the thioanisole oxidation by a range of possible oxidants originating from a reaction mixture of a Mn(III) complex with iodosylbenzene. We show here that actually there are multiple isomeric iodosylarene complexes in solution and a number of those react with substrates with rate-determining barriers at par with high-valent metal-oxo species. In particular, the [Mn-III(PhIO)], [Mn-V(O)(PhIO)] and [Mn-IV(O)-I(Ph)-O-center dot] complexes are identified as competitive oxidants and as such care should be taken with interpreting experimental rate constants.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available