Journal
APPLIED BIOLOGICAL CHEMISTRY
Volume 61, Issue 5, Pages 489-497Publisher
SPRINGER SINGAPORE PTE LTD
DOI: 10.1007/s13765-018-0382-4
Keywords
Antiaflatoxigenic; Antifungal; Carvacrol; 1-methyl-4-(1-methylethyl)-benzene; Gene expression; Membrane; Sporulation; Thymol
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Funding
- Bio-Synergy Research Project of the Ministry of Science [NRF-2013M3A9C4078156]
- Chung-Ang University Graduate Research Scholarship
- Chung-Ang University Young Scientist Scholarship (CAYSS)
- BK21 Plus (Brain Korea 21 Program for Leading Universities & Students) Scholarship, Republic of Korea
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Three monoterpenes, 1-methyl-4-(1-methylethyl)-benzene, and its derivatives, carvacrol and thymol, were tested for their antifungal and antiaflatoxigenic activities against Aspergillus flavus, and their potential in vitro mechanisms were evaluated. The monoterpenes significantly inhibited mycelial growth, spore production, and aflatoxin production in a dose-dependent manner. Furthermore, their antifungal effects were related to the suppression of fungal development regulatory genes (brlA, abaA, and wetA) and inhibition of ergosterol synthesis. Additionally, the down-regulation of the relative expression of genes related to aflatoxin biosynthesis (aflD, aflK, aflQ, and aflR) revealed an antiaflatoxigenic mechanism of the monoterpenes. These observations suggest that the three monoterpenes exhibit antiaflatoxigenic activities through multiple modes of action and may be useful for controlling aflatoxin contamination in food.
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