Journal
ACS SENSORS
Volume 3, Issue 7, Pages 1362-1367Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acssensors.8b00292
Keywords
electrochemiluminescent spectrum; simultaneous multiple biomarkers detection; monochromatic luminophore; carbon nitride; coupled instruments
Funding
- National Natural Science Foundation of China [21775018, 21675022]
- Natural Science Foundation of Jiangsu Province [BK20160028, BK20170084]
- Open Funds of the State Key Laboratory of Electroanalytical Chemistry [SKLEAC201703]
- Fundamental Research Funds for the Central Universities
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The sensitive simultaneous detection of multiple biomarkers is critical for the early diagnosis of diseases. Electrochemiluminescence (ECL) offers outstanding advantages, e.g., low background, over other optical sensing techniques. However, multiplexed ECL bioassay is hindered not only by the lack of generally available ECL spectrometers but also by the limited number of biocompatible monochromatic ECL luminophores for decades. Herein, we report addressing these issues by re-examination of the recent tabletop spectrofluorometer coupled potentiostat as a high-resolution ECL spectrum acquisition system and using carbon nitrides as monochromatic luminophores. A wavelength-resolved multiplexing ECL biosensor is demonstrated to simultaneously detect CA19-9 and mesothelin, two pancreatic cancer biomarkers, at a single-electrode interface. This work could initiate new opportunities for more general multiplex ECL biosensors with competitive performances.
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