Journal
ACS SENSORS
Volume 3, Issue 5, Pages 903-919Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acssensors.8b00257
Keywords
biosensor; DNA nanostructures; framework nucleic acids; in vitro detection; intracellular sensing
Funding
- Ministry of Science and Technology of China [2016YFA0201200, 2016YFA0400900, 201SCB559100, 2016YFC0903402]
- National Natural Science Foundation of China [21775034, 21675167, 21675041]
- National Science Foundation for Distinguished Young Scholars of Hubei Province [2018CFA041]
- Hubei Province health and family planning scientific research project [WJ2017Q032]
- Key Research Program of Frontier Sciences [QYZDJ-SSW-SLH031]
- Open Large Infrastructure Research of CAS, Chinese Academy of Sciences
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Nucleic acids have been actively exploited to develop various exquisite nanostructures due to their unparalleled programmability. Especially, framework nucleic acids (FNAs) with tailorable functionality and precise addressability hold great promise for biomedical applications. In this review, we summarize recent progress of FNA-enabled biosensing in homogeneous solutions, on heterogeneous surfaces, and inside cells. We describe the strategies to translate the structural order and rigidity of FNAs to interfacial engineering with high controllability, and approaches to realize multiplexing for highly parallel in vitro detection. We also envision the marriage of the currently available FNA tool sets with other emerging technologies to develop a new generation of biosensors for precision diagnosis and bioimaging.
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