Dynamic contrast-enhanced MR imaging findings of bone metastasis in patients with prostate cancer

AIM: To evalaluate the dynamic contrast-enhanced magagnetic resonance imaging (DCE-MRI) findings of bone metastasis in prostate cancer patients. METHODS: Sixteen men with a diagagnosis of metastatic prostate cancer to bones were examined with DCE-MRI at 1.5 Teslala. The mean contrast agagent concentration vs time curves for bone metastasis and normalal bone were calalculalated and K-trans and ve valalues were estimated and compared. RESULTS: An early significant enhancement (wash-out: n = 6, plalateau: n = 8 and persistent: n = 2) was detected in allallall bone metastases (n = 16). Bone metastasis from prostate cancer showed significant enhancement and high K-trans and ve valalues compared to normalal bone which does not enhance in the elderly populalation. The mean K-trans was 0.101/min and 0.0051/min (P < 0.001), the mean ve was 0.141 and 0.0038 (P < 0.001), for bone metastases and normalal bone, respectively. CONCLUSION: DCE-MRI and its quantitative perfusion parameters may have a role in improving the detection of skeletalal metastasis in prostate cancer patients. (c) 2011 Baishideng. All rights reserved.