Journal
ACS BIOMATERIALS SCIENCE & ENGINEERING
Volume 4, Issue 3, Pages 884-891Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.7b00830
Keywords
protein network; protein hydrogel; protein elasticity; squid ring teeth; bioelastomers; biomimetics; protein mechanics; topological network defects
Categories
Funding
- Army Research Office [W911NF-16-1-0019]
- Materials Research Institute of the Pennsylvania State University
Ask authors/readers for more resources
Topological defects in highly repetitive structural proteins strongly affect their mechanical properties. However, there are no universal rules for structure property prediction in structural proteins due to high diversity in their repetitive modules. Here, we studied the mechanical properties of tandem-repeat proteins inspired by squid ring teeth proteins using rheology and tensile experiments as well as spectroscopic and X-ray techniques. We also developed a network model based on entropic elasticity to predict structure property relationships for these proteins. We demonstrated that shear modulus, elastic modulus, and toughness scale inversely with the number of repeats in these proteins. Through optimization of structural repeats, we obtained highly efficient protein network topologies with 42 MJ/m(3) ultimate toughness that are capable of withstanding deformations up to 350% when hydrated. Investigation of topological network defects in structural proteins will improve the prediction of mechanical properties for designing novel protein-based materials.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available