Journal
ACS BIOMATERIALS SCIENCE & ENGINEERING
Volume 4, Issue 3, Pages 963-972Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.7b00886
Keywords
photothermal therapy; photodynamic therapy; gold nanoparticles; porphyrin derivative
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Funding
- National Natural Science Foundation of China [21571084]
- Natural Science Foundation of Jiangsu Province [BK20150135]
- MOE & SAFEA for the 111 Project [B13025]
- Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, Jiangnan University [JDSJ2015-06]
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Gold nanoparticles (Au NPs) have been confirmed to show excellent photothermal conversion property for tumor theranostic applications. To improve the antitumor efficacy, a novel nanoplatform system composed of porphyrin derivative and Au NPs was fabricated to study the dual-modality photodynamic and photothermal therapy with laser irradiation. Modified chitosan was coated on the Au NPs surface via ligand exchange between thiol groups and Au. The chitosan-coated Au NPs (QCS-SH/Au NPs) were further conjugated with meso-tetrakis(4-sulphonatophenyl)porphyrin (TPPS) via electrostatic interaction to obtain the porphyrin-conjugated Au hybrid nanoparticles (TPPS/QCS-SH/Au NPs). Size, morphology, and properties of the prepared nanoparticles were confirmed by Zeta potential, nanoparticle size analyzer, transmission electron microscopy (TEM), and UV-vis spectroscopy. Moreover, both photothermal therapy (PTT) and photodynamic therapy (PDT) were investigated. Compared with alone Au NPs or TPPS, the hybrid TPPS/QCS-SH/Au NPs with lower cytotoxicity showed durable elevated temperature to around 56 degrees C and large amount of singlet oxygen (O-1(2)) produced from TPPS. Thus, the hybrid nanoparticles showed a more significant synergistic therapy effect of hyperthermia from PTT as well as O-1(2) from PDT, which has potential applications in the tumor therapy fields.
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