Journal
ACS BIOMATERIALS SCIENCE & ENGINEERING
Volume 4, Issue 5, Pages 1730-1737Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.8b00260
Keywords
polymeric nanoparticle; drug delivery; lignin; renewable biopolymer; self-assembly; hydroxyl camptothecin
Categories
Funding
- National Natural Science Foundation of China [21406013, 21576029]
- Beijing college students' innovation project [S201710022045]
Ask authors/readers for more resources
The clinical applications of natural anticancer drugs are being restricted by poor water solubility, fast clearance in the circulation, lack of targeting to tumor cells, and poor tissue penetration. To address these problems, in this study, we developed a novel lignin-based targeted polymeric nanoparticles (NPs) platform, folic acid-polyethylene glycol-alkaline lignin conjugates (FA-PEG-AL), via self-assembly for delivery of anticancer drug (hydroxyl camptothecin, HCPT). These lignin-based nanoparticles had moderate particle size (similar to 150 nm) with a narrow size distribution (PDI < 0.1), exhibited excellent biocompatibility, high drug loading efficiency (similar to 24.2 wt % of HCPT), prolonged blood circulation time (similar to 7-fold of free HCPT), and enhanced cellular uptake (similar to 5-fold of free HCPT). Besides, the drug biodistribution study confirmed preferred accumulation of FA-PEG-AL/HCPT NPs in tumor tissue. Subsequent tumor xenograft test revealed superior tumor suppression efficacy and reduced side effects of FAPEG-AL/HCPT NPs compared with free HCPT. Therefore, the prepared lignin-based FA-PEG-AL/HCPT NPs would be a promising candidate for anticancer drugs delivery.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available