Journal
ACS BIOMATERIALS SCIENCE & ENGINEERING
Volume 4, Issue 5, Pages 1661-1668Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.8b00011
Keywords
rh-aFGF; carbomer 940; diabetes model; stability; bioactivity
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Funding
- National Natural Science Foundation of China [81601695]
- Natural Science Foundation of Zhejiang Province [LY17H150002]
- Wenzhou Science and Technology Agency [2015Y0520, Y20150105, Y20150104]
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Hydrogels are excellent drug delivery carriers with excellent ductility. Here, we report the design of a higher biostability of a recombinant human acidic fibroblast growth factor (rh-aFGF) carbomer hydrogel formulation. To verify the optimality of this formula, we prepared various prescriptions and tested the resulting physical properties including micromorphology, long-term stability, accelerated stability, and destructive test. Furthermore, the efficacy for promoting wound healing in full-thickness injury and scald wound diabetic rat models was explored. We found that rh-aFGF-carbomer hydrogel had good physical properties. It was stable for 24 months at 5 +/- 3 degrees C, and for 6 months at 25 +/- 3 degrees C. In vivo, the rh-aFGF-carbomer 940 hydrogel achieved a remarkable promotion of skin wound healing in diabetic rats with full-thickness injuries or scald wounds. Our data suggest that rh-aFGFcarbomer hydrogel may have applications for the treatment of diabetic ulcers combined with other wounds.
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