Journal
AMERICAN JOURNAL OF PATHOLOGY
Volume 185, Issue 1, Pages 17-25Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ajpath.2014.08.025
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Funding
- NIH [R01 AR056296, R01 CA163507, R01 AI101935]
- American Lebanese Syrian Associated Charities (ALSAC)
- St. Jude Children's Research Hospital
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Caspase-8 is an initiator and apical activator caspase that plays a central rote in apoptosis. Caspase-8-deficient mice are embryonic lethal, which makes study of caspase-8 in primary immune cells difficult. Recent advances have rescued caspase-8-deficient mice by crossing them to mice deficient in receptor-interacting serine-threonine kinase 3 (RIPK3). These genetic tools have made it possible to study the role of caspase-8 in vivo and in primary immune cells. Several recent studies have identified novel roles for caspase-8 in modulating IL-1 beta and inflammation, showing that caspase-8 directly regulates IL-1 beta independent of inflammasomes or indirectly through the regulation of inflammasomes, depending on the stimulus or stimuli that initiate the signaling cascade. Here, we address recent findings on caspase-8 and its role in modulating IL-1 beta and inflammation.
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