Journal
INFECTION AND DRUG RESISTANCE
Volume 11, Issue -, Pages 805-819Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IDR.S165676
Keywords
anidulafungin; caspofungin; candidemia; micafungin
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Candida species remains one of the most important causes of opportunistic infections worldwide. Invasive candidiasis (IC) is associated with considerable morbidity and mortality in liver disease (LD) patients if not treated promptly. Echinocandins are often recommended as a first-line empirical treatment for managing IC and can especially play a critical role in managing IC in LD patients. However, advanced LD patients are often immunocompromised and critically ill. Hence altered pharmacokinetics, drug interactions as well as tolerance issues of antifungal treatments are a concern in these patients. This comprehensive review examines the epidemiology, risk factors and diagnosis of IC in patients with LD and evaluates differences between three available echinocandins for treating this group of patients.
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