Journal
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
Volume 5, Issue 4, Pages 502-506Publisher
WILEY
DOI: 10.1002/acn3.546
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Funding
- National Institutes of Health [R01 NS041922, R01 NS089659]
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We present longitudinal imaging data of a child with Sturge-Weber syndrome (SWS). At age 8 months, 3 weeks after initial seizures and prolonged motor deficit, MRI showed extensive right hemispheric SWS involvement with severe glucose hypometabolism on PET. She was treated with levetiracetam and aspirin. Follow-up imaging at age 29 months showed a robust interval expansion of enlarged deep medullary veins throughout the affected hemisphere along with a dramatic recovery of hemispheric metabolism and normalized neurocognitive functioning. These findings demonstrate a robust, multilobar hemispheric remodeling of deep venous collaterals that likely contributed to reversal of initial metabolic and neurocognitive deficits.
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