Journal
FRONTIERS IN CHEMISTRY
Volume 6, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fchem.2018.00226
Keywords
sponge-derived fungus; Aspergillus violaceofuscus; cyclic peptides; structural characterization; anti-inflammatory
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Funding
- National Natural Science Fund for Distinguished Young Scholars of China [81225023]
- National Natural Science Fund of China [U1605221, 81741151, 41476121]
- Shanghai Municipal Commission of Health and Family Planning [20140388]
- Fund of the Science and Technology Commission of Shanghai Municipality [15431900900]
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Three new cyclic peptides including a cyclic tetrapeptide (1), an aspochracin-type cyclic tripeptide sclerotiotide L(2) and a diketopiperazine dimer (3), have been isolated from the ethyl acetate extract of a marine sponge-derived fungus Aspergillus violaceofuscus. The structures of all compounds were unambiguously elucidated on the basis of HRESIMS, 1D and 2D NMR spectroscopic data, MS/MS experiments and chemical methods. Compounds 1 and 3 showed anti-inflammatory activity against IL-10 expression of the LPS-induced THP-1 cells with inhibitory rates of 84.3 and 78.1% respectively at concentration of 10 mu M.
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