Journal
FRONTIERS IN CHEMISTRY
Volume 6, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fchem.2018.00160
Keywords
fluorine; lanthanide; iron; magnetic resonance imaging; magnetic resonance spectroscopy; contrast agent; molecular probe; responsive probe
Categories
Funding
- National Science Foundation [CAREER 1151665]
- NSF INFEWS N/P/H2O:SusChEM [CHE-1610832]
Ask authors/readers for more resources
Fluorine magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI) of chemical and physiological processes is becoming more widespread. The strength of this technique comes from the negligible background signal in in vivo F-19 MRI and the large chemical shift window of F-19 that enables it to image concomitantly more than one marker. These same advantages have also been successfully exploited in the design of responsive F-19 probes. Part of the recent growth of this technique can be attributed to novel designs of F-19 probes with improved imaging parameters due to the incorporation of paramagnetic metal ions. In this review, we provide a description of the theories and strategies that have been employed successfully to improve the sensitivity of F-19 probes with paramagnetic metal ions. The Bloch-Wangsness-Redfield theory accurately predicts how molecular parameters such as internuclear distance, geometry, rotational correlation times, as well as the nature, oxidation state, and spin state of the metal ion affect the sensitivity of the fluorine-based probes. The principles governing the design of responsive F-19 probes are subsequently described in a how to guide format. Examples of such probes and their advantages and disadvantages are highlighted through a synopsis of the literature.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available