Journal
AIDS AND BEHAVIOR
Volume 15, Issue 8, Pages 1829-1833Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10461-010-9814-9
Keywords
Sexual risk behavior; Bipolar disorder; Substance dependence; Mania; Cocaine
Funding
- NIAID NIH HHS [P30 AI064518, P30-AI064518] Funding Source: Medline
- NIDA NIH HHS [K24 DA022288-03, R01 DA015968-04, R01 DA015968, K24 DA022288-05, K24 DA022288-04, K24-DA022288, R01 DA015968-02, T32-DA01536, R01 DA015968-01, R01 DA015968-03, K24 DA022288, K24 DA022288-02, R01 DA015968-05, R01 DA15968] Funding Source: Medline
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Risky sexual behavior is common among individuals with bipolar and substance use disorders. This 15-month prospective study examined the effects of between-subject differences and within-subject changes in mood symptoms and drug use on sexual risk behavior among 61 patients with both disorders. Participants completed five post-treatment follow-up assessments at 3-month intervals. Using a multivariate mixed-effects model analysis, more average weeks of mania (between-subject difference) was associated with greater sexual risk, but change in weeks of mania (within-subject change) was not; depression was unrelated to sexual risk. In addition, within-subject increases in days of cocaine use predicted increases in sexual risk. Results underscore the importance of substance abuse treatment and suggest that bipolar patients with active and/or recurrent mania are in need of targeted HIV prevention services. Further research is needed to test whether individual differences in impulsivity may explain the association between mania and sexual risk.
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