Journal
ACS CENTRAL SCIENCE
Volume 4, Issue 2, Pages 230-234Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscentsci.7b00554
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Funding
- JSPS KAKENHI [JP17H06350]
- PRESTO (Japan Science and Technology Agency) [JPMJPR15Q9]
- Grants-in-Aid for Scientific Research [15H05955] Funding Source: KAKEN
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DWARF14 (D14) is a strigolactone receptor that plays a central role in suppression of shoot branching, and hence is a potential target to increase crop productions and biomass. Recently, we reported a fluorescence turn-on probe, Yoshimulactone Green (YLG), which generates a strong fluorescence upon the hydrolysis by D14-type strigolactone receptors. Herein, we applied a YLG-based in vitro assay to a high-throughput chemical screening and identified a novel small molecule DL1 as a potent inhibitor of D14. DL1 competes with endogenous strigolactones, thereby increasing the number of shoot branching in a model plant Arabidopsis as well as in rice. Thus, DL1 is expected to be useful not only as a tool to understand the biological roles of D14 receptors in plant growth and development, but also as a potent agrochemical to improve the crop yield.
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