Journal
RESULTS IN PHYSICS
Volume 9, Issue -, Pages 113-120Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.rinp.2018.02.003
Keywords
Biomaterial; Pore; Cellulose; Tissue engineering; Scaffold; Film
Funding
- Yeungnam University
- Basic Science Research Program of the National Research Foundation of Korea (NRF) - Ministry of Education [NRF-2016R1A6A3A11930280]
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Regarding the porous structure, coagulated cellulose may not provide sufficient voids for cell proliferation, resulting in tissue growth. For this reason, it was blended with poly(m-phenylene isophthalamide) (PMIA), which could produce a porous structure in the resulting construct. The aim of this study was to confirm the potential of a novel cellulose/PMIA porous film as a tissue-engineered bioconstruct for impaired skin. The films were fabricated by a coagulation process added with a peel-off method, and the structural, mechanical properties were characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, and capillary flow porometry. CRL-2310 human keratinocytes were used to determine the biocompatibility of the prepared films. The attachment and proliferation of cells were investigated by scanning electron microscopy, DAPI staining, and a cell viability assay. The results show that cellulose/PMIA porous films have potential use as wound matrices for skin tissue genesis. (C) 2018 Published by Elsevier B.V.
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