Journal
REDOX BIOLOGY
Volume 14, Issue -, Pages 465-473Publisher
ELSEVIER
DOI: 10.1016/j.redox.2017.10.015
Keywords
Glyoxalase pathway; Neuron; Flavonoid; Antioxidant; Neurodegenerative disease; Neuroprotection; Detoxification; Neurons viable
Categories
Funding
- Nebraska Research Initiative Award
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The glyoxalase pathway functions to detoxify reactive dicarbonyl compounds, most importantly methylglyoxal. The glyoxalase pathway is an antioxidant defense mechanism that is essential for neuroprotection. Excessive concentrations of methylglyoxal have deleterious effects on cells, leading to increased levels of inflammation and oxidative stress. Neurodegenerative diseases - including Alzheimer's, Parkinson's, Aging and Autism Spectrum Disorder - are often induced or exacerbated by accumulation of methylglyoxal. Antioxidant compounds possess several distinct mechanisms that enhance the glyoxalase pathway and function as neuroprotectants. Flavonoids are well-researched secondary plant metabolites that appear to be effective in reducing levels of oxidative stress and inflammation in neural cells. Novel flavonoids could be designed, synthesized and tested to protect against neurodegenerative diseases through regulating the glyoxalase pathway.
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