Journal
REDOX BIOLOGY
Volume 16, Issue -, Pages 59-74Publisher
ELSEVIER
DOI: 10.1016/j.redox.2018.01.015
Keywords
Cancer; Redox regulation; Natural killer cells; Cytotoxic lymphocytes; Chemotherapeutics; Free radicals; Antioxidants
Categories
Funding
- National Research, Development and Innovation Office [GINOP-2.3.2-15-2016-00020 TUMORDNS, GINOP-2.3.2-15-2016-00048-STAYALIVE, OTKA K112336]
- OTKA [PD116845]
- Bolyai [BO/00468/17/8]
- National Institutes of Health, USA [ES023864]
- Polish National Science Centre [DEC-2013/11/D/NZ2/00033]
- Polish Ministry of Science and Higher Education [776/STYP/11/2016]
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R56ES023864, R01ES023864] Funding Source: NIH RePORTER
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Redox regulation has been proposed to control various aspects of carcinogenesis, cancer cell growth, metabolism, migration, invasion, metastasis and cancer vascularization. As cancer has many faces, the role of redox control in different cancers and in the numerous cancer-related processes often point in different directions. In this review, we focus on the redox control mechanisms of tumor cell destruction. The review covers the tumor intrinsic role of oxidants derived from the reduction of oxygen and nitrogen in the control of tumor cell proliferation as well as the roles of oxidants and antioxidant systems in cancer cell death caused by traditional anticancer weapons (chemotherapeutic agents, radiotherapy, photodynamic therapy). Emphasis is also put on the role of oxidants and redox status in the outcome following interactions between cancer cells, cytotoxic lymphocytes and tumor infiltrating macrophages.
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