4.7 Article

Radical fluoroalkylthiolation of aldehydes with PhSO2SRf (Rf = CF3, C2F5, CF2H or CH2F): a general protocol for the preparation of fluoroalkylthioesters

Journal

ORGANIC CHEMISTRY FRONTIERS
Volume 5, Issue 14, Pages 2163-2166

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c8qo00327k

Keywords

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Funding

  1. National Natural Science Foundation of China [21625206, 21632009, 21572258, 21421002]
  2. Strategic Priority Research Program of the Chinese Academy of Sciences [XDB20000000]

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A general method for the preparation of fluoroalkylthioesters including trifluoromethylthio/pentafluoroethylthio/difluoromethylthio/monofluoromethylthio-esters from aldehydes and a corresponding fluoroalkylthiolating reagent was reported. The reactions were conducted under mild conditions and various common functional groups such as fluorine, chloride, bromide, iodide, and ester groups were compatible.

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