Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 5, Issue 15, Pages 2303-2307Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8qo00382c
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- Guangzhou University [2700050378]
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We report a Zn(OTf)(2) catalyzed Ugi-type reaction of 3-(2-isocyanoethyl)indoles and indole-derived ketimines to rapidly afford hexacyclic spiroindolines featuring three stereocenters including two quaternary stereocenters in moderate to excellent yields (30-89%) with complete diastereoselectivity. This reaction is highly efficient because two C-C and one C-N bonds as well as two new rings are created under mild reaction conditions in a single step.
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