Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 5, Issue 9, Pages 1516-1521Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8qo00210j
Keywords
-
Categories
Funding
- Persian Gulf University
Ask authors/readers for more resources
A novel, green and high yielding preparation of poly-substituted pyrazolyl-1,2-diazepine derivatives is described via a one-pot pseudo-seven-component condensation reaction under catalyst-free conditions in EtOH at room temperature. For this synthesis, at first, 1,1-bis(methylthio)-2-nitroethylene (BMTNE) was reacted with NH2NH2 center dot H2O to form 1,1-dihydrazino-2-nitroethylene (DHNE). Then, the addition of aryl aldehydes and malononitrile afforded the corresponding products under aerobic oxidation in good to excellent yields. This synthetic procedure for the preparation of biologically important compounds provides several benefits such as high functional group tolerance, readily available starting materials, simplicity in operation and workup and mild reaction conditions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available