Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 5, Issue 6, Pages 1049-1066Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7qo01079f
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Funding
- National Natural Science Foundation of China [21772044]
- China Postdoctoral Science Foundation [2017M611490]
- Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT)
- National Young Top-Notch Talent Support Program, the Fundamental Research Funds for the Central Universities
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The Mannich reaction has been widely used to effectively construct C-N and C-C bonds in organic synthesis. This review focuses on selected applications of the intramolecular Mannich reaction as a key step in the total synthesis of natural products (2000-2017). The organization of the synthetic applications is based on the structure of newly-formed skeletons using the intramolecular Mannich reaction, which include aza-fused rings and aza-bridged rings.
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