4.7 Article

Synthesis of chiral γ-aminophosphonates through the organocatalytic hydrophosphonylation of azadienes with phosphites

Journal

ORGANIC CHEMISTRY FRONTIERS
Volume 5, Issue 7, Pages 1148-1151

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c7qo01158j

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Funding

  1. National Natural Science Foundation of China [20102348]
  2. Chinese Academy of Sciences [QYZDJ-SSW-SLH035]
  3. Strategic Priority Research Program of the Chinese Academy of Sciences [XDB17020300]
  4. Dalian Bureau of Science and Technology [2016RD07]

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An organocatalytic enantioselective 1,4-addition of phosphites to azadienes has been successfully developed using quinine as a catalyst, providing an efficient and facile route to optically active -aminophosphonates with up to 94% ee.

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