4.7 Article

Application of a rhodium-catalyzed cyclization cycloaddition cascade strategy to the total synthesis of (-)-curcumol

Journal

ORGANIC CHEMISTRY FRONTIERS
Volume 5, Issue 7, Pages 1092-1095

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c7qo01150d

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Funding

  1. National Natural Science Foundation of China [21372203, 21272076]
  2. State Key Laboratory of Synthetic Chemistry
  3. University of Hong Kong

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A de novo asymmetric total synthesis of (-)-curcumol has been realized, based on a rhodium-catalyzed cyclization-cycloaddition cascade reaction as the key step to construct the tricyclic nucleus.

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