Journal
OPTICA
Volume 5, Issue 4, Pages 413-422Publisher
OPTICAL SOC AMER
DOI: 10.1364/OPTICA.5.000413
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Funding
- Air Force Office of Scientific Research (AFOSR) [FA9550-12-1-0321]
- National Institutes of Health (NIH) [NCI R01 CA171651]
- National Science Foundation (NSF) [1724615, 1740737]
- Division Of Ocean Sciences
- Directorate For Geosciences [1724615] Funding Source: National Science Foundation
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1740737] Funding Source: National Science Foundation
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Image-guided surgery can enhance cancer treatment by decreasing, and ideally eliminating, positive tumor margins and iatrogenic damage to healthy tissue. Current state-of-the-art near-infrared fluorescence imaging systems are bulky and costly, lack sensitivity under surgical illumination, and lack co-registration accuracy between multimodal images. As a result, an overwhelming majority of physicians still rely on their unaided eyes and palpation as the primary sensing modalities for distinguishing cancerous from healthy tissue. Here we introduce an innovative design, comprising an artificial multispectral sensor inspired by the Morpho butterfly's compound eye, which can significantly improve image-guided surgery. By monolithically integrating spectral tapetal filters with photodetectors, we have realized a single-chip multispectral imager with 1000 x higher sensitivity and 7 x better spatial co-registration accuracy compared to clinical imaging systems in current use. Preclinical and clinical data demonstrate that this technology seamlessly integrates into the surgical workflow while providing surgeons with real-time information on the location of cancerous tissue and sentinel lymph nodes. Due to its low manufacturing cost, our bio-inspired sensor will provide resource-limited hospitals with much-needed technology to enable more accurate value-based health care. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
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