Journal
ONCOIMMUNOLOGY
Volume 7, Issue 6, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/2162402X.2018.1431089
Keywords
anthracyclines; cancer; chemotherapy; ER stress; unfolded protein response
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Funding
- Bristol-Myers Squibb research grant
- Ligue contre le Cancer Comite de Charente-Maritime (equipe labelisee)
- Agence National de la Recherche (ANR)
- ANR under the frame of E-Rare-2
- ERA-Net for Research on Rare Diseases
- Association pour la recherche sur le cancer (ARC)
- Canceropole Ile-de-France
- Chancelerie des universites de Paris (Legs Poix)
- Fondation pour la Recherche Medicale (FRM)
- Philantropia grant
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Immunogenic cell death (ICD) induced by anticancer chemotherapeutics is usually preceded by premortem stress affecting the endoplasmic reticulum (ER). This ER stress does not reflect a canonical unfolded protein response (UPR) but rather manifests solely at the level of the phosphorylation of eIF2 alpha. eIF2 alpha phosphorylation is hence a quintessential hallmark of ICD that can be detected by immunohistochemistry in tumor samples.
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