Journal
MOLECULAR METABOLISM
Volume 9, Issue -, Pages 187-191Publisher
ELSEVIER
DOI: 10.1016/j.molmet.2017.12.016
Keywords
Skeletal muscle; Growth differentiation factor 15; Recovery; Physical activity
Categories
Funding
- Novo-Nordisk A/S
- Danish Council for Independent Research/Medicine [4004-00233, 4092-00309]
- Lundbeck Foundation [R238-2016-2859]
- Novo Nordisk Foundation [NNF170C0026114]
- Novo Nordisk Foundation
- Lundbeck Foundation [R238-2016-2859] Funding Source: researchfish
- NNF Center for Basic Metabolic Research [Clemmensen Group] Funding Source: researchfish
- Novo Nordisk Fonden [NNF17OC0026114] Funding Source: researchfish
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Objective: The growth differentiation factor 15 (GDF15) is a stress-sensitive circulating factor that regulates systemic energy balance. Since exercise is a transient physiological stress that has pleiotropic effects on whole-body energy metabolism, we herein explored the effect of exercise on a) circulating GDF15 levels and b) GDF15 release from skeletal muscle in humans. Methods: Seven healthy males either rested or exercised at 67% of their VO2max for 1 h and blood was sampled from the femoral artery and femoral vein before, during, and after exercise. Plasma GDF15 concentrations were determined in these samples. Results: Plasma GDF15 levels increased 34% with exercise (p < 0.001) and further increased to 64% above resting values at 120 min (p < 0.001) after the cessation of exercise. There was no difference between the arterial and venous GDF15 concentration before, during, and after exercise. During a resting control trial, GDF15 levels measured in the same subjects were unaltered. Conclusions: Vigorous submaximal exercise increases circulating GDF15 levels in humans, but skeletal muscle tissue does not appear to be the source. (C) 2018 The Authors. Published by Elsevier GmbH.
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