Journal
MICROBIOME
Volume 6, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s40168-018-0475-7
Keywords
Amniotic fluid; Microbiome; Virome; Sterile body fluid; Virus; Bacteria; Microbial invasion of the amniotic cavity
Categories
Funding
- Children's Discovery Institute [MD-FR-2013-292]
- Doris Duke Charitable Foundation [2017076]
- March of Dimes [BOC 388999]
- Washington University Institute of Clinical and Translational Sciences by the NIH/ National Center for Advancing Translational Sciences (NCATS), CTSA [UL1TR000448]
- NIH [R00 DK107923]
- Arizona State University startup funding
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Recent studies have conflicting data regarding the presence of intra-amniotic microbiota. Viral communities are increasingly recognized as important although overlooked components of the human microbiota. It is unknown if the developing fetus is exposed to a community of viruses (virome). Given the debate over the existence of an intraamniotic microbial community and the importance of understanding how the infant gut is populated, we characterized the virome and bacterial microbiota of amniotic fluid from 24 uncomplicated term pregnancies using next-generation sequencing methods. Contrary to expectations, the bacterial microbiota of amniotic fluid was indistinguishable from contamination controls. Viral reads were sparse in the amniotic fluid, and we found no evidence of a core viral community across samples.
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