Journal
MICROBIOME
Volume 6, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s40168-018-0479-3
Keywords
Gut microbiome; Genome-wide association studies (GWAS); Meta-analysis
Categories
Funding
- COPSAC, Copenhagen Prospective Studes on Asthma in Childhood, Herlev and Gentofte, Hospital, University of Copenhagen, Copenhagen, Denmark
- Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel
- Department of Molecular Cell Biology, Weizmann Institute, of Science Rehovot, Israel
- Division of Gastroenterology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
- Department of Twin Research and Genetic Epidemiology, King's College London, London, UK
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan, MI, USA
- University of Groningen, University Medical Center Groningen, Department Genetics, Groningen, The Netherlands
- European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK
- Department of Biological Psychology, Amsterdam Public Heath Research Institute, VU Amsterdam, Amsterdam, The Netherlands
- Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada
- Avera Institute for Human Genetics, Avera McKennan Hospital & University Health Center, Sioux Falls, SD, USA
- Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany
- Unit of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
- Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada
- Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
- Health Science Center at Houston, University of Texas, Houston, TN, USA
- Department of Medicine A, University Medicine Greifswald, Greifswald, Germany
- Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Germany
- MRC Integrative Epidemiology Unit at University of Bristol, Bristol, UK
- Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
- Department of Internal Medicine, Diabetes Centre, VU University Medical Centre, Amsterdam, The Netherlands
- Division of Gastroenterology-Hepatology, Department of Internal Medicine, NUTRIM School of Nutrition and Translational Research in, Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands
- Department of Biochemistry, School of Medicine, Ewha Womans University, Seoul, South Korea
- Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
- Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio, University Hospital, Kuopio, Finland
- Laboratory of Epidemiology and Population Science, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
- Institute of Genomics, University of Tartu, Estonia
- Department of Medicine, Department of Human Genetics, Molecular Biology Institute, Department of Microbiology, Immunology and Molecular Genetics, University of California, CA, USA
- Department of Medicine 2, University Hospital, Ludwig-Maximilians-University, Munich, Germany
- The Generation R Study Group, Erasmus MC, 3000 CA Rotterdam, The Netherlands
- Department of Epidemiology, Erasmus MC, 3000 CA Rotterdam, The Netherlands
- Department of Nutrition, Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, USA
- Department of Genetics, University of North Carolina at Chapel Hill, NC, USA
- Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
- Genetics and Genome Biology, The Hospital for Sick Children Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
- Departments of Neurology and Genetics, University of Alabama at Birmingham, Birmingham, AL, USA
- Department of Microbiology and Immunology, Rega Institute. KU Leuven - University of Leuven, Leuven, Belgium
- VIB Center for Microbiology, Leuven, Belgium
- Department of Psychiatry, Radboudumc, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands
- Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
- Institute for Community Medicine, Greifswald University Hospital, Greifswald, Germany
- K.G. Jebsen Coeliac Disease Re. search Centre, Department of Immunology, University of Oslo, Norway
- Department of Biostatistics, Princess Margaret Cancer Centre, Toronto, Ontario, Canada
- MRC [MR/N01183X/1, MR/N030125/1, MC_UU_12013/3] Funding Source: UKRI
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Background: In recent years, human microbiota, especially gut microbiota, have emerged as an important yet complex trait influencing human metabolism, immunology, and diseases. Many studies are investigating the forces underlying the observed variation, including the human genetic variants that shape human microbiota. Several preliminary genome-wide association studies (GWAS) have been completed, but more are necessary to achieve a fuller picture. Results: Here, we announce the MiBioGen consortium initiative, which has assembled 18 population-level cohorts and some 19,000 participants. Its aim is to generate new knowledge for the rapidly developing field of microbiota research. Each cohort has surveyed the gut microbiome via 16S rRNA sequencing and genotyped their participants with full-genome SNP arrays. We have standardized the analytical pipelines for both the microbiota phenotypes and genotypes, and all the data have been processed using identical approaches. Our analysis of microbiome composition shows that we can reduce the potential artifacts introduced by technical differences in generating microbiota data. We are now in the process of benchmarking the association tests and performing meta-analyses of genome-wide associations. All pipeline and summary statistics results will be shared using public data repositories. Conclusion: We present the largest consortium to date devoted to microbiota-GWAS. We have adapted our analytical pipelines to suit multi-cohort analyses and expect to gain insight into host-microbiota cross-talk at the genome-wide level. And, as an open consortium, we invite more cohorts to join us (by contacting one of the corresponding authors) and to follow the analytical pipeline we have developed.
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