Journal
ANNALS OF BEHAVIORAL MEDICINE
Volume 42, Issue 3, Pages 321-333Publisher
OXFORD UNIV PRESS INC
DOI: 10.1007/s12160-011-9294-9
Keywords
Gynecologic cancer; Fatigue; Depression; Actigraphy; Sleep; Chemotherapy
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Funding
- NCI NIH HHS [R03 CA126775, K07 CA138499] Funding Source: Medline
- PHS HHS [K07-138499, R03-126775] Funding Source: Medline
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Previous research suggests that cancer patients frequently experience multiple symptoms during chemotherapy; however, relationships among symptom changes are largely unknown. The aim of the current study was to examine daily and intraday changes and interrelationships among fatigue, depression, and objectively measured disruptions in sleep and activity during chemotherapy. Participants were 78 women with gynecologic cancer. Fatigue, depression, sleep, and activity were assessed the week before and the week after the participants' first three infusions. Significant changes in fatigue, depression, sleep, and activity were observed over time. Before infusions, increases in fatigue were associated with increases in depression. After infusions, increases in fatigue were associated with increases in depression and minutes awake at night, as well as decreases in daytime activity and regularity of sleep/activity patterns (ps < .05). This study is among the first to track daily and intraday changes in symptoms and interrelationships during chemotherapy. Results indicate that symptoms are interrelated and return to baseline levels after infusions.
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