Facile synthesis of 3-aryl-1-((4-aryl-1,2,3-selenadiazol-5-yl) sulfanyl) isoquinolines

A new series of 1,2,3-selenadiazoles containing an aryl or a 3-arylisoquinoline sulfanyl moiety at carbons 4 and 5, respectively, was prepared by cyclization of the respective semicarbazones in the presence of selenium(II) oxide and tetrahydrofuran at 70-75 degrees C. Semicarbazones required for the reaction were obtained from 2-((3-arylisoquinolin-1-yl) sulfanyl)-1-phenylethanones, I, by a reaction with semicarbazide hydrochloride in ethanol/water mixture and potassium acetate base. (C) 2011 Institute of Chemistry, Slovak Academy of Sciences