Journal
JOURNAL OF CELL COMMUNICATION AND SIGNALING
Volume 12, Issue 1, Pages 205-210Publisher
SPRINGER
DOI: 10.1007/s12079-018-0452-8
Keywords
Extracellular signaling molecule; SLRP family; Tsukushi; Vertebrate development
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Tsukushi (TSK) is a small signaling molecule which takes part in different developmental processes of multiple vertebrate organisms. The diverse activity of TSK depends on its ability to bind various intermediate molecules from different major signaling pathways. Interactions of TSK with BMP, FGF, TGF-ss and Wnt pathways have already been confirmed. In this review, we will introduce the latest information regarding the involvement of TSK in developmental events. We suggest a fine tuning role for TSK in multiple signaling cascades. Also, we recommend further studies on the developmental role of TSK to fully reveal its potential.
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