Journal
INORGANIC CHEMISTRY FRONTIERS
Volume 5, Issue 1, Pages 73-83Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7qi00446j
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Funding
- Spanish MINECO [SAF-2012-34424, CTQ2015-68779R, CTQ2015-70371-REDT]
- University Policies (SPU, Argentina)
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Two Pd(II) and Pt(II) complexes with two pyrrol-2-carbaldehyde N-p-chlorophenylthiosemicarbazone ligands are designed and characterized showing mononuclear structures. An important pharmacological property for both compounds is the high selectivity for tumor cells and a lack of activity in healthy cells. The Pd(II) compound shows a higher antitumor activity and selectivity than the Pt(II) compound. Both complexes present a variety of biological interactions: with DNA models (pBR322 and CT DNA), proteins (lysozyme and RNase) and other biological targets like proteosome. Our results show that the Pd(II) complex is a more interesting candidate for potential anticancer therapies than the Pt(II) complex, and we provide new insight into the design and synthesis of palladium compounds as potential antitumor agents.
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