Journal
JOURNAL OF THE KOREAN CHEMICAL SOCIETY-DAEHAN HWAHAK HOE JEE
Volume 55, Issue 6, Pages 936-939Publisher
KOREAN CHEMICAL SOC
DOI: 10.5012/jkcs.2011.55.6.936
Keywords
Thiamine hydrochloride; Biginelli reaction; Octahydroquinazolinone derivatives; Microwave-irradiation; Solvent-free
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Thiamine hydrochloride (VB1) has been used as an acid catalyst in organic synthesis. One pot three component Biginelli condensation of dimedone, urea/thiourea and substituted aromatic aldehydes catalyzed by 10 mol % of thiamine hydrochloride (VB1) in solvent free condition under microwave irradiation in good to excellent yields has been investigated. Utilization of microwave irradiation, simple reaction conditions, short reaction time, ease of product isolation, and purification makes this manipulation very interesting from an economic and environmental perspective.
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