Journal
GIGASCIENCE
Volume 7, Issue 4, Pages -Publisher
OXFORD UNIV PRESS
DOI: 10.1093/gigascience/giy014
Keywords
biological networks; graph theory; systems biology; bipartite graphs; ecological networks; network medicine
Categories
Funding
- US Department of Energy (DOE) Joint Genome Institute, a DOE Office of Science User Facility [DE-AC02-05CH11231]
- Office of Science of the DOE
Ask authors/readers for more resources
The latest advances in high-throughput techniques during the past decade allowed the systems biology field to expand significantly. Today, the focus of biologists has shifted from the study of individual biological components to the study of complex biological systems and their dynamics at a larger scale. Through the discovery of novel bioentity relationships, researchers reveal new information about biological functions and processes. Graphs are widely used to represent bioentities such as proteins, genes, small molecules, ligands, and others such as nodes and their connections as edges within a network. In this review, special focus is given to the usability of bipartite graphs and their impact on the field of network biology and medicine. Furthermore, their topological properties and how these can be applied to certain biological case studies are discussed. Finally, available methodologies and software are presented, and useful insights on how bipartite graphs can shape the path toward the solution of challenging biological problems are provided.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available