Journal
FRONTIERS OF MEDICINE
Volume 12, Issue 1, Pages 23-33Publisher
SPRINGER
DOI: 10.1007/s11684-017-0607-7
Keywords
genome sequencing; genomic epidemiology; bacteria; surveillance; infectious diseases
Categories
Funding
- National Key Basic Research Program of the Ministry of Health of China [2015CB554201]
- National Key Research and Development Program of the Ministry of Health of China [2016YFC1200103]
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Two decades have passed since the first bacterial whole-genome sequencing, which provides new opportunity for microbial genome. Consequently, considerable genetic diversity encoded by bacterial genomes and among the strains in the same species has been revealed. In recent years, genome sequencing techniques and bioinformatics have developed rapidly, which has resulted in transformation and expedited the application of strategy and methodology for bacterial genome comparison used in dissection of infectious disease epidemics. Bacterial whole-genome sequencing and bioinformatic computing allow genotyping to satisfy the requirements of epidemiological study in disease control. In this review, we outline the significance and summarize the roles of bacterial genome sequencing in the context of bacterial disease control and prevention. We discuss the applications of bacterial genome sequencing in outbreak detection, source tracing, transmission mode discovery, and new epidemic clone identification. Wide applications of genome sequencing and data sharing in infectious disease surveillance networks will considerably promote outbreak detection and early warning to prevent the dissemination of bacterial diseases.
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