Journal
FRONTIERS OF MEDICINE
Volume 12, Issue 1, Pages 98-103Publisher
SPRINGER
DOI: 10.1007/s11684-018-0614-3
Keywords
Cyclospora cayetanensis; outpatients with diarrhea; stool specimens; 18S rRNA gene
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Funding
- Chinese Special Program for Scientific Research of Public Health [201302004, 201502021]
- National Key Research and Development Program of China [2016YFC1201900]
- Fourth Round of Three-Year Public Health Action Plan of Shanghai, China [15GWZK0101]
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Cyclospora cayetanensis is a foodborne and waterborne pathogen that causes endemic and epidemic human diarrhea worldwide. A few epidemiological studies regarding C. cayetanensis infections in China have been conducted. During 2013, a total of 291 stool specimens were collected from patients with diarrhea at a hospital in urban Shanghai. C. cayetanensis was not detected in any of the stool specimens by traditional microscopy, whereas five stool specimens (1.72%, 5/291) were positive by PCR. These positive cases confirmed by molecular technology were all in the adult group (mean age 27.8 years; 2.94%, 5/170) with watery diarrhea. Marked infection occurred in the rainy season of May and July. Sequence and phylogenetic analyses of the partial 18S rRNA genes of C. cayetanensis isolated showed intra-species diversity of this parasite. This study showed, for the first time, that C. cayetanensis is a pathogen in outpatients with diarrhea in Shanghai, albeit at a low level. However, the transmission dynamics of this parasite in these patients remain uncertain.
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