Journal
FRONTIERS IN IMMUNOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.00298
Keywords
epigenetics; monocytes; immunometabolism; innate immune memory; rheumatoid arthritis; systemic lupus erythematosus; Wegener's granulomatosis; hyper Ig-D syndroom
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Funding
- ERC Consolidator Grant [310372]
- Spinoza Grant of the Netherlands Organization for Scientific Research
- Competitiveness Operational Programme grant of the Romanian Ministry of European Funds (HINT) [P_37_762, MySMIS 103587]
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During induction of trained immunity, monocytes and macrophages undergo a functional and transcriptional reprogramming toward increased activation. Important rewiring of cellular metabolism of the myeloid cells takes place during induction of trained immunity, including a shift toward glycolysis induced through the mTOR pathway, as well as glutaminolysis and cholesterol synthesis. Subsequently, this leads to modulation of the function of epigenetic enzymes, resulting in important changes in chromatin architecture that enables increased gene transcription. However, in addition to the beneficial effects of trained immunity as a host defense mechanism, we hypothesize that trained immunity also plays a deleterious role in the induction and/or maintenance of autoimmune and autoinflammatory diseases if inappropriately activated.
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