Journal
FRONTIERS IN IMMUNOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.00546
Keywords
microRNAs; nuclear factor kappa B; cancer; molecular therapy; nuclear factor kappa B-associated resistance
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Funding
- National Natural Science Foundation of China [31472185, U1703104, 31201900]
- National Key Basic Research Program (973 program) of China [2015CB150300]
- State Public-interest Institution Basal Research Fund [1610312016017]
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Nuclear factor kappa B (NF-kappa B) is a pluripotent and crucial dimer transcription factor that orchestrates various physiological and pathological processes, especially cell proliferation, inflammation, and cancer development and progression. NF-kappa B expression is transient and tightly regulated in normal cells, but it is activated in cancer cells. Recently, numerous studies have demonstrated microRNAs (miRNAs) play a vital role in the NF-kappa B signaling pathway and NF-kappa B-associated immune responses, radioresistance and drug resistance of cancer, some acting as inhibitors and the others as activators. Although it is still in infancy, targeting NF-kappa B or the NF-kappa B signaling pathway by miRNAs is becoming a promising strategy of cancer treatment.
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