Journal
FRONTIERS IN IMMUNOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.00286
Keywords
aryl hydrocarbon receptor; tumor immunity; tumor development; immune surveillance; cancer immunotherapy
Categories
Funding
- NSFC of China [81671561]
- National Key R&D Program of China [2016YFC1305102]
- 1000 Young Talents Plan Program of China
- Fudan Children's Hospital
- Fudan University
- Shanghai Municipal Planning Commission of science and Research Fund [201740065]
- Shanghai Pujiang Program [16PJ1401600]
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The aryl hydrocarbon receptor (AhR) is an important cytosolic, ligand-dependent transcription factor. Emerging evidence suggests the promoting role of the AhR in the initiation, promotion, progression, invasion, and metastasis of cancer cells. Studies on various tumor types and tumor cell lines have shown high AhR expression, suggesting that AhR is activated constitutively in tumors and facilitates their growth. Interestingly, immune evasion has been recognized as an emerging hallmark feature of cancer. A connection between the AhR and immune system has been recognized, which has been suggested as an immunosuppressive effector on different types of immune cells. Certain cancers can escape immune recognition via AhR signaling pathways. This review discusses the role of the AhR in tumor immunity and its potential mechanism of action in the tumor microenvironment.
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